Authors
DA Stead, RME Richards
Publication date
1997/6/6
Journal
Journal of Chromatography B: Biomedical Sciences and Applications
Volume
693
Issue
2
Pages
415-421
Publisher
Elsevier
Description
Following the development of a sensitive high-performance liquid chromatographic (HPLC) assay for gentamicin in biological matrices, the utility of this assay for the determination of other clinically important aminoglycosides (neomycin, netilmicin and sisomicin) in bacterial culture media or plasma is demonstrated. The high sensitivity of the assay enables direct measurement of the aminoglycoside content of bacterial cells cultured in the presence of unlabelled drug.
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DA Stead, RME Richards - Journal of Chromatography B: Biomedical Sciences …, 1997