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The current investigation employed Chitosan/nTiO 2 nanocomposite (CTNC) adsorbent to sequester Cu (II) ions from the aqueous medium by column adsorption. The experimentations were executed at optimum pH 6.5 under variable operating conditions, viz. bed depths (3-7 cm), flow rates (10-30 ml min-1) and Cu (II) concentration (10-30 mg L-1). Seven kinetic models checked experimental records. Thomas model was established to be the best-fit model correlated to a bed height of 5 cm, inner diameter of column 1.5 cm, the influent flow rate of 10 mlmin-1, and the initial Cu (II) concentration of 30 mg L-1. The potential application of multiple linear regression (MLR) and genetic algorithm (GA) techniques to forecast the elimination of Cu (II) are also verified.