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Long-term exposure of Cr(VI) causes severe health effects to the living beings. A continuous fixed bed experimental study is carried out by using pistachio shell as green and eco-friendly adsorbent for Cr(VI) adsorption. Effects of several operating parameters on Cr(VI) removal were investigated using the breakthrough curves ( versus time) and determination of saturation time ( Cr(VI) adsorption equilibrium was illustrated by Langmuir isotherm. Different kinetic models like Yan et al. (2001), Thomas (1944), Yoon-Nelson (1984), and Bohart-Adams model(1920) were applied to study the dynamics of the adsorption process.Yan et al. model was found more effective compare to other kinetic models.This studyshowed that the pistachio shells, green adsorbent, have potential adsorption capacity for Cr(VI) ions. Applicability of GA-ANN hybrid model has been tested to predict the percentage removal of …