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The ANN approach proved its worth when rigorous fluid mechanics treatment based on the solution of first principle equations is not tractable. Evaluation and prediction of the frictional pressure drop across different piping components such as orifices, gate and globe valves, elbows, and horizontal pipe in 0.0127 m diameter for gas non-Newtonian liquid flow is manifested in this paper. In this paper, we have used the power-law-model (Oswald−de Waele model) liquids only. The experimental data used for the prediction is taken from our earlier work, Bandyopadhyay (Bandyopadhyay, T. K. Studies on non-Newtonian and gas-non-Newtonian liquid flow through horizontal tube and piping components. Ph.D Thesis, University of Calcutta, Kolkata, India, 2002) and the subsequent publications (Banerjee T. K.; Das, S. K. Gas-non-Newtonian liquid flow through globe and gate valves. Chem. Eng. Commun. 1998, 167, 133 …