Authors
Maria C Rodriguez-Oroz, JA Obeso, AE Lang, J-L Houeto, P Pollak, Stig Rehncrona, J Kulisevsky, A Albanese, J Volkmann, MI Hariz, NP Quinn, JD Speelman, J Guridi, I Zamarbide, A Gironell, J Molet, B Pascual-Sedano, B Pidoux, AM Bonnet, Y Agid, J Xie, A-L Benabid, AM Lozano, J Saint-Cyr, L Romito, MF Contarino, Massimo Scerrati, V Fraix, N Van Blercom
Publication date
2005/10/1
Journal
Brain
Volume
128
Issue
10
Pages
2240-2249
Publisher
Oxford University Press
Description
Deep brain stimulation (DBS) is associated with significant improvement of motor complications in patients with severe Parkinson's disease after some 6–12 months of treatment. Long-term results in a large number of patients have been reported only from a single study centre. We report 69 Parkinson's disease patients treated with bilateral DBS of the subthalamic nucleus (STN, n = 49) or globus pallidus internus (GPi, n = 20) included in a multicentre study. Patients were assessed preoperatively and at 1 year and 3–4 years after surgery. The primary outcome measure was the change in the ‘off’ medication score of the Unified Parkinson's Disease Rating Scale motor part (UPDRS-III) at 3–4 years. Stimulation of the STN or GPi induced a significant improvement (50 and 39%; P < 0.0001) of the ‘off’ medication UPDRS-III score at 3–4 years with respect to baseline. Stimulation improved cardinal features and …
Total citations
Scholar articles
MC Rodriguez-Oroz, JA Obeso, AE Lang, JL Houeto… - Brain, 2005