Authors
Margaret R Spitz, Xifeng Wu, Yunfei Wang, Li-E Wang, Sanjay Shete, Christopher I Amos, Zhaozheng Guo, Lei Lei, Harvey Mohrenweiser, Qingyi Wei
Publication date
2001/2/2
Journal
Cancer research
Volume
61
Issue
4
Pages
1354-1357
Publisher
American Association for Cancer Research
Description
Sequence variations have been identified in a number of DNA repair genes, including XPD, but the effect of these polymorphisms on DNA repair capacity (DRC) is uncertain. We therefore examined XPD polymorphisms at Lys751Gln and Asp312Asn in 341 white lung cancer cases and 360 age-,sex-, ethnicity-, and smoking-matched controls accrued in a hospital-based molecular epidemiological study of susceptibility markers for lung cancer. As previously reported, DRC was statistically significantly lower in the cases than in the controls (7.8%versus 9.5%; P < 0.001),which represents an average 18% reduction among the cases. The variant Lys751Gln and Asp312Asn allele frequencies were 0.36 and 0.29, respectively, for the cases and 0.33 and 0.27, respectively, for the controls. For subjects homozygous for the variant genotype at either locus, the adjusted odds ratio [95%confidence interval (CI)] was 1.84 …
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Scholar articles
MR Spitz, X Wu, Y Wang, LE Wang, S Shete, CI Amos… - Cancer research, 2001