Authors
Frank C Arnett, Pravitt Gourh, Sanjay Shete, Chul W Ahn, Robert E Honey, Sandeep K Agarwal, Filemon K Tan, Terry McNearney, Michael Fischbach, Marvin J Fritzler, Maureen D Mayes, John D Reveille
Publication date
2010/5/1
Journal
Annals of the rheumatic diseases
Volume
69
Issue
5
Pages
822-827
Publisher
BMJ Publishing Group Ltd
Description
Objective
To determine human leucocyte antigen-class II (HLA-class II) (DRB1, DQB1, DQA1 and DPB1) alleles, haplotypes and shared epitopes associated with scleroderma (systemic sclerosis (SSc)) and its subphenotypes in a large multi-ethnic US cohort by a case–control association study.
Patients and methods
1300 SSc cases (961 white, 178 black and 161 Hispanic subjects) characterised for clinical skin forms (limited vs diffuse), SSc-specific autoantibodies (anticentromere (ACA), anti-topoisomerase I (ATA), anti-RNA polymerase III (ARA), anti-U3 ribonucleoprotein (fibrillarin)) and others were studied using molecular genotyping. Statistical analyses in SSc itself by ethnicity, gender, skin type and autoantibodies were performed using exact logistic regression modelling for dominant, additive and recessive effects from HLA.
Results
The strongest positive class II associations with SSc in white and Hispanic …
Total citations
Scholar articles
FC Arnett, P Gourh, S Shete, CW Ahn, RE Honey… - Annals of the rheumatic diseases, 2010