Authors
Preetha Rajaraman, Beatrice S Melin, Zhaoming Wang, Roberta McKean-Cowdin, Dominique S Michaud, Sophia S Wang, Melissa Bondy, Richard Houlston, Robert B Jenkins, Margaret Wrensch, Meredith Yeager, Anders Ahlbom, Demetrius Albanes, Ulrika Andersson, Laura E Beane Freeman, Julie E Buring, Mary Ann Butler, Melissa Braganza, Tania Carreon, Maria Feychting, Sarah J Fleming, Susan M Gapstur, J Michael Gaziano, Graham G Giles, Goran Hallmans, Roger Henriksson, Judith Hoffman-Bolton, Peter D Inskip, Christoffer Johansen, Cari M Kitahara, Mark Lathrop, Chenwei Liu, Loic Le Marchand, Martha S Linet, Stefan Lonn, Ulrike Peters, Mark P Purdue, Nathaniel Rothman, Avima M Ruder, Marc Sanson, Howard D Sesso, Gianluca Severi, Xiao-Ou Shu, Matthias Simon, Meir Stampfer, Victoria L Stevens, Kala Visvanathan, Emily White, Alicja Wolk, Anne Zeleniuch-Jacquotte, Wei Zheng, Paul Decker, Victor Enciso-Mora, Brooke Fridley, Yu-Tang Gao, Matthew Kosel, Daniel H Lachance, Ching Lau, Terri Rice, Anthony Swerdlow, Joseph L Wiemels, John K Wiencke, Sanjay Shete, Yong-Bing Xiang, Yuanyuan Xiao, Robert N Hoover, Joseph F Fraumeni, Nilanjan Chatterjee, Patricia Hartge, Stephen J Chanock
Publication date
2012/12
Journal
Human genetics
Volume
131
Pages
1877-1888
Publisher
Springer-Verlag
Description
Gliomas account for approximately 80 % of all primary malignant brain tumors and, despite improvements in clinical care over the last 20 years, remain among the most lethal tumors, underscoring the need for gaining new insights that could translate into clinical advances. Recent genome-wide association studies (GWAS) have identified seven new susceptibility regions. We conducted a new independent GWAS of glioma using 1,856 cases and 4,955 controls (from 14 cohort studies, 3 case–control studies, and 1 population-based case-only study) and found evidence of strong replication for three of the seven previously reported associations at 20q13.33 (RTEL), 5p15.33 (TERT), and 9p21.3 (CDKN2BAS), and consistent association signals for the remaining four at 7p11.2 (EGFR both loci), 8q24.21 (CCDC26) and 11q23.3 (PHLDB1). The direction and magnitude of the signal were consistent for samples …
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Scholar articles
P Rajaraman, BS Melin, Z Wang, R McKean-Cowdin… - Human genetics, 2012