View article

A catabolite-responsive element (CRE), a binding site for the CcpA transcription factor, was identified within the sigL structural gene encoding σ^L in Bacillus subtilis. We show that CcpA binds to this CRE to regulate sigL expression by a “roadblock” mechanism and that this mechanism in part accounts for catabolite repression of σ^L-directed levD operon expression.