Authors
Barak Menagen, David Avnir
Publication date
2020/6/5
Journal
Materials Research Express
Volume
7
Issue
6
Pages
065404
Publisher
IOP Publishing
Description
Iron and its alloys have been widely used for variety of medical implants. These are used for long term applications as cheap implants with high inertness and low corrosion rate, and also as implants with high biocompatibility (the fourth-generation type). Such degrading implants can provide a temporary scaffold while the body heals. In addition to the needed mechanical support, it is highly desirable to provide local drug therapy, providing antibacterial properties, preventing rejection of the implant, and more. So far, the combination of a degradable metallic implant which serves also as a three-dimensional matrix for drug release, remained un-answered. Here we present, we believe for the first time realization of this concept: Entrapment of drugs within a 3D degradable metal matrix—iron—from which the entrapped drugs are sustain-released. This new type of material is based on the molecular metals entrapment …
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