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Wireless body sensor networks (BSNs) possess enormous potential for changing people's daily lives. They can enhance many human-centered application domains such as m-Health, sport and wellness, and human-centered applications that involve physical/virtual social interactions. However, there are still challenging issues that limit their wide diffusion in real life: primarily, the programming complexity of these systems, due to the lack of high-level software abstractions, and the hardware constraints of wearable devices. In contrast with low-level programming and general-purpose middleware, domain-specific frameworks are an emerging programming paradigm designed to fulfill the lack of suitable BSN programming support with proper abstraction layers. This paper analyzes the most important requirements for an effective BSN-specific software framework, enabling efficient signal-processing applications …