Authors
Andri Rauch, Zoltán Kutalik, Patrick Descombes, Tao Cai, Julia Di Iulio, Tobias Mueller, Murielle Bochud, Manuel Battegay, Enos Bernasconi, Jan Borovicka, Sara Colombo, Andreas Cerny, Jean–François Dufour, Hansjakob Furrer, Huldrych F Günthard, Markus Heim, Bernard Hirschel, Raffaele Malinverni, Darius Moradpour, Beat Müllhaupt, Andrea Witteck, Jacques S Beckmann, Thomas Berg, Sven Bergmann, Francesco Negro, Amalio Telenti, Pierre–Yves Bochud
Publication date
2010/4/1
Journal
Gastroenterology
Volume
138
Issue
4
Pages
1338-1345. e7
Publisher
WB Saunders
Description
BACKGROUND & AIMS
Hepatitis C virus (HCV) induces chronic infection in 50% to 80% of infected persons; approximately 50% of these do not respond to therapy. We performed a genome-wide association study to screen for host genetic determinants of HCV persistence and response to therapy.
METHODS
The analysis included 1362 individuals: 1015 with chronic hepatitis C and 347 who spontaneously cleared the virus (448 were coinfected with human immunodeficiency virus [HIV]). Responses to pegylated interferon alfa and ribavirin were assessed in 465 individuals. Associations between more than 500,000 single nucleotide polymorphisms (SNPs) and outcomes were assessed by multivariate logistic regression.
RESULTS
Chronic hepatitis C was associated with SNPs in the IL28B locus, which encodes the antiviral cytokine interferon lambda. The rs8099917 minor allele was associated with progression …
Total citations
Scholar articles
A Rauch, Z Kutalik, P Descombes, T Cai, J Di Iulio… - Gastroenterology, 2010
A Rauch, Z Kutalik, P Descombes, T Cai, J Di Iulio… - Gastroenterology, 2010