Authors
Jing Yan, Shenghai Zhang, Kay Ka-Wai Li, Weiwei Wang, Ke Li, Wenchao Duan, Binke Yuan, Li Wang, Lei Liu, Yunbo Zhan, Dongling Pei, Haibiao Zhao, Tao Sun, Chen Sun, Wenqing Wang, Zhen Liu, Xuanke Hong, Xiangxiang Wang, Yu Guo, Wencai Li, Jingliang Cheng, Xianzhi Liu, Ho-Keung Ng, Zhicheng Li, Zhenyu Zhang
Publication date
2020/11/1
Journal
EBioMedicine
Volume
61
Publisher
Elsevier
Description
Background
To develop a radiomics signature for predicting overall survival (OS)/progression-free survival (PFS) in patients with medulloblastoma (MB), and to investigate the incremental prognostic value and biological pathways of the radiomics patterns.
Methods
A radiomics signature was constructed based on magnetic resonance imaging (MRI) from a training cohort (n = 83), and evaluated on a testing cohort (n = 83). Key pathways associated with the signature were identified by RNA-seq (GSE151519). Prognostic value of pathway genes was assessed in a public GSE85218 cohort.
Findings
The radiomics-clinicomolecular signature predicted OS (C-index 0.762) and PFS (C-index 0.697) better than either the radiomics signature (C-index: OS: 0.649; PFS: 0.593) or the clinicomolecular signature (C-index: OS: 0.725; PFS: 0.691) alone, with a better calibration and classification accuracy (net reclassification …
Scholar articles
J Yan, S Zhang, KKW Li, W Wang, K Li, W Duan… - EBioMedicine, 2020