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Instructional design for technology-mediated learning is a well-substantiated process serving a community of practitioners that spans K-20 education and workplace training. However, instructional design has been mired in 20th century pedagogies, principles, and technologies that have only limited capabilities into evolving into useful and resourceful learning strategies and tools for the 21st century (see McGee, Carmean, & Jafari, 2005). The panelists each present approaches to instructional design that illustrate the emerging shift from instruction to construction and will engage the audience in interactive 21st century learning experiences.