Authors
Daniel Glass, Ana Viñuela, Matthew N Davies, Adaikalavan Ramasamy, Leopold Parts, David Knowles, Andrew A Brown, Åsa K Hedman, Kerrin S Small, Alfonso Buil, Elin Grundberg, Alexandra C Nica, Paola Di Meglio, Frank O Nestle, Mina Ryten, UK Brain Expression consortium tim. spector@ kcl. ac. uk, MuTHER consortium muther@ kcl. ac. uk, Richard Durbin, Mark I McCarthy, Panagiotis Deloukas, Emmanouil T Dermitzakis, Michael E Weale, Veronique Bataille, Tim D Spector
Publication date
2013/7
Journal
Genome biology
Volume
14
Pages
1-12
Publisher
BioMed Central
Description
Background
Previous studies have demonstrated that gene expression levels change with age. These changes are hypothesized to influence the aging rate of an individual. We analyzed gene expression changes with age in abdominal skin, subcutaneous adipose tissue and lymphoblastoid cell lines in 856 female twins in the age range of 39-85 years. Additionally, we investigated genotypic variants involved in genotype-by-age interactions to understand how the genomic regulation of gene expression alters with age.
Results
Using a linear mixed model, differential expression with age was identified in 1,672 genes in skin and 188 genes in adipose tissue. Only two genes expressed in lymphoblastoid cell lines showed significant changes with age. Genes significantly regulated by age were compared with expression profiles in 10 brain regions from 100 …
Scholar articles
D Glass, A Viñuela, MN Davies, A Ramasamy, L Parts… - Genome biology, 2013