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The current paper puts forward integration methodology of Lean, Agile, Resilience, and Green which eventually build up LARGe supply chain. Integration is being discussed from five viewpoints for each of the four approaches and eventually for LARG supply chain as a new approach in supply chain which is rooted on those four while having its own identity. Integration methodology of LARGe supply chain is introduced as a journey (so called LARGe path) which covers its characteristics, organizational system, human and technology factors, information systems, and performance measures. The walk through this path is the main challenge to achieve SC competitiveness and innovation. This methodology encompasses the major variables that govern supply chain management, which will accomplish a deep understanding of the influences of SC’s paradigms on the ground perspective.