Authors
Jon E Tyson, Nehal A Parikh, John Langer, Charles Green, Rosemary D Higgins
Publication date
2008/4/17
Journal
New England Journal of Medicine
Volume
358
Issue
16
Pages
1672-1681
Publisher
Massachusetts Medical Society
Description
Background
Decisions regarding whether to administer intensive care to extremely premature infants are often based on gestational age alone. However, other factors also affect the prognosis for these patients.
Methods
We prospectively studied a cohort of 4446 infants born at 22 to 25 weeks' gestation (determined on the basis of the best obstetrical estimate) in the Neonatal Research Network of the National Institute of Child Health and Human Development to relate risk factors assessable at or before birth to the likelihood of survival, survival without profound neurodevelopmental impairment, and survival without neurodevelopmental impairment at a corrected age of 18 to 22 months.
Results
Among study infants, 3702 (83%) received intensive care in the form of mechanical ventilation. Among the 4192 study infants (94%) for whom outcomes were determined at 18 to 22 months, 49% died, 61% died or had …
Total citations
Scholar articles
JE Tyson, NA Parikh, J Langer, C Green, RD Higgins - New England Journal of Medicine, 2008