Authors
Laurent Béchard, Charles Desmeules, Lauryann Bachand, Maxime Huot-Lavoie, Olivier Corbeil, Elizabeth Anderson, Sébastien Brodeur, Annie LeBlanc, Marie-France Demers, Sophie Lauzier, Marc-André Roy
Publication date
2024/1/22
Source
European Psychiatry
Pages
1-34
Publisher
Cambridge University Press
Description
Background: The optimal duration of antipsychotic treatment following remission of first episode psychosis (FEP) is uncertain, considering potential adverse effects and individual variability in relapse rates. This study aimed to investigate the effect of antipsychotic discontinuation compared to continuation on recovery in remitted FEP patients.
Methods: CENTRAL, MEDLINE (Ovid), Embase, and PsycINFO were searched on November 2, 2023, with no language restrictions. Randomized controlled trials (RCTs) evaluating antipsychotic discontinuation in remitted FEP patients were selected. The primary outcome was personal recovery, and secondary outcomes included functional recovery, global functioning, hospital admission, symptom severity, quality of life, side effects, and employment. Risk of bias was assessed using the Cochrane riskof-bias tool 2, and certainty of evidence was evaluated with GRADE. Meta …
Total citations
20241
Scholar articles
L Béchard, C Desmeules, L Bachand, M Huot-Lavoie… - European Psychiatry, 2024