Authors
Karoline B Kuchenbaecker, Susan J Ramus, Jonathan Tyrer, Andrew Lee, Howard C Shen, Jonathan Beesley, Kate Lawrenson, Lesley McGuffog, Sue Healey, Janet M Lee, Tassja J Spindler, Yvonne G Lin, Tanja Pejovic, Yukie Bean, Qiyuan Li, Simon Coetzee, Dennis Hazelett, Alexander Miron, Melissa Southey, Mary Beth Terry, David E Goldgar, Saundra S Buys, Ramunas Janavicius, Cecilia M Dorfling, Elizabeth J Van Rensburg, Susan L Neuhausen, Yuan Chun Ding, Thomas VO Hansen, Lars Jønson, Anne-Marie Gerdes, Bent Ejlertsen, Daniel Barrowdale, Joe Dennis, Javier Benitez, Ana Osorio, Maria Jose Garcia, Ian Komenaka, Jeffrey N Weitzel, Pamela Ganschow, Paolo Peterlongo, Loris Bernard, Alessandra Viel, Bernardo Bonanni, Bernard Peissel, Siranoush Manoukian, Paolo Radice, Laura Papi, Laura Ottini, Florentia Fostira, Irene Konstantopoulou, Judy Garber, Debra Frost, Jo Perkins, Radka Platte, Steve Ellis, EMBRACE, Andrew K Godwin, Rita Katharina Schmutzler, Alfons Meindl, Christoph Engel, Christian Sutter, Olga M Sinilnikova, GEMO Study Collaborators, Francesca Damiola, Sylvie Mazoyer, Dominique Stoppa-Lyonnet, Kathleen Claes, Kim De Leeneer, Judy Kirk, Gustavo C Rodriguez, Marion Piedmonte, David M O'Malley, Miguel de la Hoya, Trinidad Caldes, Kristiina Aittomäki, Heli Nevanlinna, J Margriet Collée, Matti A Rookus, Jan C Oosterwijk, Breast Cancer Family Registry, Laima Tihomirova, Nadine Tung, Ute Hamann, Claudine Isaccs, Marc Tischkowitz, Evgeny N Imyanitov, Maria A Caligo, Ian G Campbell, Frans BL Hogervorst, HEBON, Edith Olah, Orland Diez, Ignacio Blanco, Joan Brunet, Conxi Lazaro, Miquel Angel Pujana, Anna Jakubowska, Jacek Gronwald, Jan Lubinski, Grzegorz Sukiennicki, Rosa B Barkardottir, Marie Plante, Jacques Simard, Penny Soucy, Marco Montagna, Silvia Tognazzo, Manuel R Teixeira, KConFab Investigators, Vernon S Pankratz, Xianshu Wang, Noralane Lindor, Csilla I Szabo, Noah Kauff, Joseph Vijai, Carol A Aghajanian, Georg Pfeiler, Andreas Berger, Christian F Singer, Muy-Kheng Tea, Catherine M Phelan, Mark H Greene, Phuong L Mai, Gad Rennert, Anna Marie Mulligan, Sandrine Tchatchou, Irene L Andrulis, Gord Glendon, Amanda Ewart Toland, Uffe Birk Jensen, Torben A Kruse, Mads Thomassen, Anders Bojesen, Jamal Zidan, Eitan Friedman, Yael Laitman, Maria Soller, Annelie Liljegren, Brita Arver, Zakaria Einbeigi, Marie Stenmark-Askmalm, Olufunmilayo I Olopade, Robert L Nussbaum, Timothy R Rebbeck, Katherine L Nathanson, Susan M Domchek, Karen H Lu, Beth Y Karlan, Christine Walsh, Jenny Lester, Australian Cancer Study (Ovarian Cancer Investigators)
Publication date
2015/2
Journal
Nature genetics
Volume
47
Issue
2
Pages
164-171
Publisher
Nature Publishing Group US
Description
Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer (EOC) susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 and BRCA2 mutation carriers who are at high risk of EOC. After imputation to 1000 Genomes Project data, we assessed associations of 11 million genetic variants with EOC risk from 15,437 cases unselected for family history and 30,845 controls and from 15,252 BRCA1 mutation carriers and 8,211 BRCA2 mutation carriers (3,096 with ovarian cancer), and we combined the results in a meta-analysis. This new study design yielded increased statistical power, leading to the discovery of six new EOC susceptibility loci. Variants at 1p36 (nearest gene, WNT4), 4q26 (SYNPO2), 9q34.2 (ABO) and 17q11.2 (ATAD5) were associated with EOC risk, and at 1p34.3 (RSPO1) and 6p22.1 (GPX6) variants were specifically associated with the serous …
Scholar articles
KB Kuchenbaecker, SJ Ramus, J Tyrer, A Lee… - Nature genetics, 2015
J Tyrer, HC Shen, K Lawrenson, JM Lee, TJ Spindler… - Nature Genetics, 2015
SJ Ramus, J Tyrer, A Lee, HC Shen, J Beesley… - Nat Genet, 2015