Authors
Jason W Busse, Li Wang, Mostafa Kamaleldin, Samantha Craigie, John J. Riva, Luis Montoya, Sohail M. Mulla, Luciane C. Lopes, Nicole Vogel, Eric Chen, Karin Kirmayr, Kyle De Oliveira, Lori Olivieri, Alka Kaushal, Luis E. Chaparro, Inna Oyberman, Arnav Agarwal, Rachel Couban, Ludwig Tsoi, Tommy Lam, Per Olav Vandvik, Sandy Hsu, Malgorzata M. Bala, Stefan Schandelmaier, Anne Scheidecker, Shanil Ebrahim, Vahid Ashoorion, Yasir Rehman, Patrick J. Hong, Stephanie Ross, Bradley C. Johnston, Regina Kunz, Xin Sun, Norman Buckley, Daniel I. Sessler, Gordon H. Guyatt
Publication date
2018/12/18
Journal
JAMA: Journal of the American Medical Association
Volume
320
Issue
23
Pages
2448-2460
Description
Importance
Harms and benefits of opioids for chronic noncancer pain remain unclear.
Objective
To systematically review randomized clinical trials (RCTs) of opioids for chronic noncancer pain.
Data Sources and Study Selection
The databases of CENTRAL, CINAHL, EMBASE, MEDLINE, AMED, and PsycINFO were searched from inception to April 2018 for RCTs of opioids for chronic noncancer pain vs any nonopioid control.
Data Extraction and Synthesis
Paired reviewers independently extracted data. The analyses used random-effects models and the Grading of Recommendations Assessment, Development and Evaluation to rate the quality of the evidence.
Main Outcomes and Measures
The primary outcomes were pain intensity (score range, 0-10 cm on a visual analog scale for pain; lower is better and the minimally important difference [MID] is 1 cm), physical functioning (score range, 0-100 points on the 36-item …
Scholar articles
JW Busse, L Wang, M Kamaleldin, S Craigie, JJ Riva… - Jama, 2018
JW Busse, S Schandelmaier, M Kamaleldin, S Hsu… - Systematic reviews, 2013