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Neurodegenerative diseases cause progressive, impairing cognitive, behavioral, and motor function. The objective of study was to investigate grey matter changes in the amnestic Mild Cognitive Impaired (MCI) subjects as a function of time to convert to Alzheimer’s disease (AD). Risk was stratified according to time to conversion. Data used in the preparation of this article were obtained from the ADNI database. We selected individuals with a baseline diagnosis of MCI who had baseline MRI data available, and at least 4 year of clinical follow-up, baseline HC diagnosis with at least 4 year follow up, and AD patients at baseline. The MCI groups were sub-divided into 3 subgroups: stable MCI (did not covert to AD in 4 year follow up), fast converter MCI (converted within initial 18 months from baseline), and slow converter MCI (converted to AD from 2 to 4 years follow up period). The subjects were recruited from ADNI-1 the numbers in the different groups were: 58 HC, 22 stable MCI, 29 fast converter MCI, 26 slow converter MCI, and 101 AD patients. The demographics of each group are in table 1. Magnetic resonance imaging scans were collected on a 1.5 T scanner using a standardized high resolution protocol. Each participant gave written informed consent in accordance with institutional Research Ethics Committee guidelines. Quantitative analysis using Freesurfer was utilized to map cortical thickness in different regions of interest (ROI) and volumetric measures of deep grey matter structures. ROI volumes were normalized by intra-cranial volume. The statistical analysis for each grey matter structure was based on one-way …