Authors
Elizabeth G Kehoe, Jonathan P McNulty, Paul G Mullins, Arun LW Bokde
Publication date
2014/10/1
Source
Biomarkers in medicine
Volume
8
Issue
9
Pages
1151-1169
Publisher
Taylor & Francis
Description
With the prevalence of Alzheimer’s disease (AD) predicted to increase substantially over the coming decades, the development of effective biomarkers for the early detection of the disease is paramount. In this short review, the main neuroimaging techniques which have shown potential as biomarkers for AD are introduced, with a focus on MRI. Structural MRI measures of the hippocampus and medial temporal lobe are still the most clinically validated biomarkers for AD, but newer techniques such as functional MRI and diffusion tensor imaging offer great scope in tracking changes in the brain, particularly in functional and structural connectivity, which may precede gray matter atrophy. These new advances in neuroimaging methods require further development and crucially, standardization; however, before they are used as biomarkers to aid in the diagnosis of AD.
Total citations
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Scholar articles
EG Kehoe, JP McNulty, PG Mullins, ALW Bokde - Biomarkers in medicine, 2014