Authors
Ryan D Morin, Nathalie A Johnson, Tesa M Severson, Andrew J Mungall, Jianghong An, Rodrigo Goya, Jessica E Paul, Merrill Boyle, Bruce W Woolcock, Florian Kuchenbauer, Damian Yap, R Keith Humphries, Obi L Griffith, Sohrab Shah, Henry Zhu, Michelle Kimbara, Pavel Shashkin, Jean F Charlot, Marianna Tcherpakov, Richard Corbett, Angela Tam, Richard Varhol, Duane Smailus, Michelle Moksa, Yongjun Zhao, Allen Delaney, Hong Qian, Inanc Birol, Jacqueline Schein, Richard Moore, Robert Holt, Doug E Horsman, Joseph M Connors, Steven Jones, Samuel Aparicio, Martin Hirst, Randy D Gascoyne, Marco A Marra
Publication date
2010/2
Journal
Nature genetics
Volume
42
Issue
2
Pages
181-185
Publisher
Nature Publishing Group US
Description
Follicular lymphoma (FL) and the GCB subtype of diffuse large B-cell lymphoma (DLBCL) derive from germinal center B cells. Targeted resequencing studies have revealed mutations in various genes encoding proteins in the NF-κB pathway, that contribute to the activated B-cell (ABC) DLBCL subtype, but thus far few GCB-specific mutations have been identified. Here we report recurrent somatic mutations affecting the polycomb-group oncogeneEZH2, which encodes a histone methyltransferase responsible for trimethylating Lys27 of histone H3 (H3K27). After the recent discovery of mutations in KDM6A (UTX), which encodes the histone H3K27me3 demethylase UTX, in several cancer types, EZH2 is the second histone methyltransferase gene found to be mutated in cancer. These mutations, which result in the replacement of a single tyrosine in the SET domain of the EZH2 protein (Tyr641), occur in 21.7% of GCB …
Total citations
Scholar articles
RD Morin, NA Johnson, TM Severson, AJ Mungall, J An… - Nature genetics, 2010