Authors
Andreas Rosenwald, George Wright, Wing C Chan, Joseph M Connors, Elias Campo, Richard I Fisher, Randy D Gascoyne, H Konrad Muller-Hermelink, Erlend B Smeland, Jena M Giltnane, Elaine M Hurt, Hong Zhao, Lauren Averett, Liming Yang, Wyndham H Wilson, Elaine S Jaffe, Richard Simon, Richard D Klausner, John Powell, Patricia L Duffey, Dan L Longo, Timothy C Greiner, Dennis D Weisenburger, Warren G Sanger, Bhavana J Dave, James C Lynch, Julie Vose, James O Armitage, Emilio Montserrat, Armando López-Guillermo, Thomas M Grogan, Thomas P Miller, Michel LeBlanc, German Ott, Stein Kvaloy, Jan Delabie, Harald Holte, Peter Krajci, Trond Stokke, Louis M Staudt
Publication date
2002/6/20
Journal
New England Journal of Medicine
Volume
346
Issue
25
Pages
1937-1947
Publisher
Massachusetts Medical Society
Description
Background
The survival of patients with diffuse large-B-cell lymphoma after chemotherapy is influenced by molecular features of the tumors. We used the gene-expression profiles of these lymphomas to develop a molecular predictor of survival.
Methods
Biopsy samples of diffuse large-B-cell lymphoma from 240 patients were examined for gene expression with the use of DNA microarrays and analyzed for genomic abnormalities. Subgroups with distinctive gene-expression profiles were defined on the basis of hierarchical clustering. A molecular predictor of risk was constructed with the use of genes with expression patterns that were associated with survival in a preliminary group of 160 patients and was then tested in a validation group of 80 patients. The accuracy of this predictor was compared with that of the international prognostic index.
Results
Three gene-expression subgroups — germinal-center B-cell …
Total citations
Scholar articles
A Rosenwald, G Wright, WC Chan, JM Connors… - New England Journal of Medicine, 2002