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Sustainability and digital transformation represent two of the main trends of the last decade. More in detail, Industry 4.0 (I4.0) and Circular Economy (CE) are two key concepts that are characterizing the present and that will shape the future. From the extant literature review emerges that, although academics identify a possible synergy between these topics, a concrete integrated framework able to achieve CE at systemic level is still missing. The objective of this research is to put in relation the I4.0 and CE paradigms to understand the link between the two topics and envisage a new framework focused on circularity among supply chains. Therefore, a systematic literature review on CE, I4.0 and on their mutual relationship have been conducted to investigate which are the synergies and how the new I4.0 technologies support the implementation of CE at supply chains network level. Hence, a framework in which I4.0 …