Authors
Jennifer S Rabin, Aaron P Schultz, Trey Hedden, Anand Viswanathan, Gad A Marshall, Emily Kilpatrick, Hannah Klein, Rachel F Buckley, Hyun-Sik Yang, Michael Properzi, Vaishnavi Rao, Dylan R Kirn, Kathryn V Papp, Dorene M Rentz, Keith A Johnson, Reisa A Sperling, Jasmeer P Chhatwal
Publication date
2018/9/1
Journal
JAMA neurology
Volume
75
Issue
9
Pages
1124-1131
Publisher
American Medical Association
Description
Importance
Identifying asymptomatic individuals at high risk of impending cognitive decline because of Alzheimer disease is crucial for successful prevention of dementia. Vascular risk and β-amyloid (Aβ) pathology commonly co-occur in older adults and are significant causes of cognitive impairment.
Objective
To determine whether vascular risk and Aβ burden act additively or synergistically to promote cognitive decline in clinically normal older adults; and, secondarily, to evaluate the unique influence of vascular risk on prospective cognitive decline beyond that of commonly used imaging biomarkers, including Aβ burden, hippocampal volume, fludeoxyglucose F18–labeled (FDG) positron emission tomography (PET), and white matter hyperintensities, a marker of cerebrovascular disease.
Design, Setting, and Participants
In this longitudinal observational study, we examined clinically normal older adults from the …
Scholar articles
JS Rabin, AP Schultz, T Hedden, A Viswanathan… - JAMA neurology, 2018