Authors
Adam S Fleisher, Kewei Chen, Xiaofen Liu, Napatkamon Ayutyanont, Auttawut Roontiva, Pradeep Thiyyagura, Hillary Protas, Abhinay D Joshi, Marwan Sabbagh, Carl H Sadowsky, Reisa A Sperling, Christopher M Clark, Mark A Mintun, Michael J Pontecorvo, R Edward Coleman, PM Doraiswamy, Keith A Johnson, Alan P Carpenter, Daniel M Skovronsky, Eric M Reiman
Publication date
2013/1/1
Journal
Neurobiology of aging
Volume
34
Issue
1
Pages
1-12
Publisher
Elsevier
Description
OBJECTIVES
Investigate apolipoprotein E ε4 (APOE4) gene and aging effects on florbetapir F18 positron emission tomography (PET) in normal aging and Alzheimer's disease (AD).
Methods
Florbetapir F18 PET images were analyzed from 245 participants, 18–92 years of age, from Avid Radiopharmaceutical's multicenter registered trials, including 86 younger healthy control volunteers (yHC), 61 older healthy control volunteers (oHC), 53 mild cognitive impairment (MCI) patients, and 45 AD dementia patients (DAT). Mean florbetapir standard uptake value ratios (SUVRs) were used to evaluate the effects of APOE4 carrier status, older age, and their interaction in each of these groups.
Results
In comparison with non-carriers, the APOE4 carriers in each of the oHC, MCI, and DAT groups had higher mean cortical-to-cerebellar florbetapir SUVRs, patterns of florbetapir PET elevations characteristic of DAT, and a higher …
Scholar articles
AS Fleisher, K Chen, X Liu, N Ayutyanont, A Roontiva… - Neurobiology of aging, 2013