Authors
Stephen N Gomperts, Joseph J Locascio, Sara J Makaretz, Aaron Schultz, Christina Caso, Neil Vasdev, Reisa Sperling, John H Growdon, Bradford C Dickerson, Keith Johnson
Publication date
2016/11/1
Journal
JAMA neurology
Volume
73
Issue
11
Pages
1334-1341
Publisher
American Medical Association
Description
Importance
The causes of cognitive impairment in dementia with Lewy bodies (DLB) and Parkinson disease (PD) are multifactorial. Tau pathologic changes are commonly observed at autopsy in individuals with DLB and PD dementia, but their contribution to these diseases during life is unknown.
Objective
To contrast tau aggregation in DLB, cognitively impaired persons with PD (PD-impaired), cognitively normal individuals with PD (PD-normal), and healthy persons serving as control participants, and to evaluate the association between tau aggregation, amyloid deposition, and cognitive function.
Design, Setting, and Participants
This cross-sectional study was conducted from January 1, 2014, to April 28, 2016, in a tertiary care center’s memory and movement disorders units. Twenty-four patients with Lewy body disease (7 DLB, 8 PD-impaired, and 9 PD-normal) underwent multimodal brain imaging, cognitive testing …
Scholar articles
SN Gomperts, JJ Locascio, SJ Makaretz, A Schultz… - JAMA neurology, 2016