Authors
Veronica Wendy Setiawan, Iona Cheng, Daniel O Stram, Elena Giorgi, Malcolm C Pike, David Van Den Berg, Loreall Pooler, Noel P Burtt, Loic Le Marchand, David Altshuler, Joel Hirschhorn, Brian E Henderson, Christopher A Haiman
Publication date
2006/12/15
Journal
Cancer research
Volume
66
Issue
24
Pages
12019-12025
Publisher
American Association for Cancer Research
Description
CYP11A catalyzes the rate-limiting step in the biosynthesis of sex-steroid hormones. In this study, we employed a systematic approach that involved gene resequencing and a haplotype-based analysis to investigate the relationship between common variation in CYP11A and breast cancer risk among African-Americans, Latinas, Japanese-Americans, Native Hawaiians, and Whites in the Multiethnic Cohort Study. Resequencing in a multiethnic panel of 95 advanced breast cancer cases revealed no common missense variant (≥5% frequency). Common haplotype patterns were assessed by genotyping 36 densely spaced single nucleotide polymorphisms (SNPs) spanning 67 kb of the CYP11A locus in a multiethnic panel of subjects (n = 349; 1 SNP/1.86 kb on average). We identified one to two regions of strong linkage disequilibrium in these populations. Twelve tagging SNPs were selected to predict the …
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Scholar articles
VW Setiawan, I Cheng, DO Stram, E Giorgi, MC Pike… - Cancer research, 2006