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Evaluation of computing systems reliability must be accurate enough to provide hints for the required fault protection mechanisms that will guarantee correctness of operation at acceptance costs. To be useful, reliability evaluation must be performed early enough in the design cycle when, however, the available details of the system are largely unknown. This inherent contradiction in terms: early vs. accurate, requires a cross-layer approach for reliability evaluation. Different layers of abstraction contribute differently in the overall system reliability; if this contribution can be assessed independently, the reliability of the system can be evaluated at the early stages of the design. We review the state-of-the-art in the area and discuss corresponding challenges .