Authors
Frank-Gerald Pajonk, Thomas Wobrock, Oliver Gruber, Harald Scherk, Dorothea Berner, Inge Kaizl, Astrid Kierer, Stephanie Müller, Martin Oest, Tim Meyer, Martin Backens, Thomas Schneider-Axmann, Allen E Thornton, William G Honer, Peter Falkai
Publication date
2010/2/1
Journal
Archives of general psychiatry
Volume
67
Issue
2
Pages
133-143
Publisher
American Medical Association
Description
Context
Hippocampal volume is lower than expected in patients with schizophrenia; however, whether this represents a fixed deficit is uncertain. Exercise is a stimulus to hippocampal plasticity.
Objective
To determine whether hippocampal volume would increase with exercise in humans and whether this effect would be related to improved aerobic fitness.
Design
Randomized controlled study.
Setting
Patients attending a day hospital program or an outpatient clinic.
Patients or Other Participants
Male patients with chronic schizophrenia and matched healthy subjects.
Interventions
Aerobic exercise training (cycling) and playing table football (control group) for a period of 3 months.
Main Outcome Measures
Magnetic resonance imaging of the hippocampus. Secondary outcome measures were magnetic resonance spectroscopy, neuropsychological (Rey Auditory Verbal Learning Test, Corsi block-tapping test), and clinical …
Total citations
Scholar articles
FG Pajonk, T Wobrock, O Gruber, H Scherk, D Berner… - Archives of general psychiatry, 2010