Authors
Gail Davies, Nicola Armstrong, Joshua C Bis, Jan Bressler, Vincent Chouraki, Sudheer Giddaluru, Edith Hofer, Carla A Ibrahim-Verbaas, Mirna Kirin, J Lahti, Sven J van der Lee, Stephanie Le Hellard, Tian Liu, Riccardo E Marioni, Christopher Oldmeadow, Iris Postmus, Albert Vernon Smith, Jennifer Ann Smith, Anbupalam Thalamuthu, Russell Thomson, Veronique Vitart, Jing Wang, Lei Yu, Lina Zgaga, Wei Zhao, Ruth Boxall, Sarah E Harris, William David Hill, David C Liewald, Michelle Luciano, Hieab Adams, David Ames, Najaf Amin, Philippe Amouyel, Amelia A Assareh, Rhoda Au, James T Becker, Alexa Beiser, Claudine Berr, Lars Bertram, Eric Boerwinkle, Brendan M Buckley, Harry Campbell, Janie Corley, Philip Laurence De Jager, Carole Dufouil, Johan Gunnar Eriksson, Thomas Espeseth, Jessica D Faul, Ian Ford, Generation Scotland, RF Gottesman, ME Griswold, Vilmundur Gudnason, TB Harris, Gerardo Heiss, Albert Hofman, EG Holliday, Jennifer Huffman, SLR Kardia, N Kochan, DS Knopman, JB Kwok, JC Lambert, T Lee, G Li, Shu-Chen Li, Marisa Loitfelder, OL Lopez, AJ Lundervold, A Lundqvist, KA Mather, SS Mirza, L Nyberg, BA Oostra, Aarno Palotie, G Papenberg, Alison Pattie, Katja Petrovic, Ozren Polasek, BM Psaty, Paul Redmond, S Reppermund, JI Rotter, H Schmidt, Maaike Schuur, PW Schofield, RJ Scott, Vidar Martin Steen, David J Stott, JC Van Swieten, KD Taylor, J Trollor, Stella Trompet, AG Uitterlinden, G Weinstein, Elisabeth Widen, BG Windham, Jan Wouter Jukema, AF Wright, MJ Wright, Q Yang, Hélène Amieva, JR Attia, DA Bennett, Henry Brodaty, AJM De Craen, C Hayward, MA Ikram, Ulman Lindenberger, LG Nilsson, David J Porteous, Katri Räikkönen, Ivar Reinvang, Igor Rudan, PS Sachdev, R Schmidt, PR Schofield, V Srikanth, JM Starr, ST Turner, David R Weir, James F Wilson, Cornelia van Duijn, Lenore Launer, AL Fitzpatrick, Sudha Seshadri, Thomas H Mosley, IJ Deary
Publication date
2015/2
Journal
Molecular psychiatry
Volume
20
Issue
2
Pages
183-192
Publisher
Nature Publishing Group
Description
General cognitive function is substantially heritable across the human life course from adolescence to old age. We investigated the genetic contribution to variation in this important, health-and well-being-related trait in middle-aged and older adults. We conducted a meta-analysis of genome-wide association studies of 31 cohorts (N= 53 949) in which the participants had undertaken multiple, diverse cognitive tests. A general cognitive function phenotype was tested for, and created in each cohort by principal component analysis. We report 13 genome-wide significant single-nucleotide polymorphism (SNP) associations in three genomic regions, 6q16. 1, 14q12 and 19q13. 32 (best SNP and closest gene, respectively: rs10457441, P= 3.93× 10− 9, MIR2113; rs17522122, P= 2.55× 10− 8, AKAP6; rs10119, P= 5.67× 10− 9, APOE/TOMM40). We report one gene-based significant association with the HMGN1 gene …
Scholar articles
G Davies, N Armstrong, JC Bis, J Bressler, V Chouraki… - Molecular psychiatry, 2015