Authors
Riccardo E Marioni, Sonia Shah, Allan F McRae, Stuart J Ritchie, Graciela Muniz-Terrera, Sarah E Harris, Jude Gibson, Paul Redmond, Simon R Cox, Alison Pattie, Janie Corley, Adele Taylor, Lee Murphy, John M Starr, Steve Horvath, Peter M Visscher, Naomi R Wray, Ian J Deary
Publication date
2015/8/1
Journal
International journal of epidemiology
Volume
44
Issue
4
Pages
1388-1396
Publisher
Oxford University Press
Description
Background: The DNA methylation-based ‘epigenetic clock’ correlates strongly with chronological age, but it is currently unclear what drives individual differences. We examine cross-sectional and longitudinal associations between the epigenetic clock and four mortality-linked markers of physical and mental fitness: lung function, walking speed, grip strength and cognitive ability.
Methods: DNA methylation-based age acceleration (residuals of the epigenetic clock estimate regressed on chronological age) were estimated in the Lothian Birth Cohort 1936 at ages 70 (n = 920), 73 (n = 299) and 76 (n = 273) years. General cognitive ability, walking speed, lung function and grip strength were measured concurrently. Cross-sectional correlations between age acceleration and the fitness variables were calculated. Longitudinal change in the epigenetic clock estimates and the fitness variables …
Scholar articles
RE Marioni, S Shah, AF McRae, SJ Ritchie… - International journal of epidemiology, 2015