Authors
Gail Davies, Riccardo E Marioni, David C Liewald, William David Hill, Saskia P Hagenaars, Sarah E Harris, Stuart J Ritchie, Michelle Luciano, Chloe Fawns-Ritchie, Donald Lyall, Breda Cullen, Simon R Cox, Caroline Hayward, David J Porteous, Jonathan Evans, Andrew M McIntosh, John Gallacher, Nicholas Craddock, Jill P Pell, Daniel J Smith, Catherine R Gale, IJ Deary
Publication date
2016/6
Journal
Molecular psychiatry
Volume
21
Issue
6
Pages
758-767
Publisher
Nature Publishing Group
Description
People’s differences in cognitive functions are partly heritable and are associated with important life outcomes. Previous genome-wide association (GWA) studies of cognitive functions have found evidence for polygenic effects yet, to date, there are few replicated genetic associations. Here we use data from the UK Biobank sample to investigate the genetic contributions to variation in tests of three cognitive functions and in educational attainment. GWA analyses were performed for verbal–numerical reasoning (N= 36 035), memory (N= 112 067), reaction time (N= 111 483) and for the attainment of a college or a university degree (N= 111 114). We report genome-wide significant single-nucleotide polymorphism (SNP)-based associations in 20 genomic regions, and significant gene-based findings in 46 regions. These include findings in the ATXN2, CYP2DG, APBA1 and CADM2 genes. We report replication of these …
Scholar articles
G Davies, RE Marioni, DC Liewald, WD Hill… - Molecular psychiatry, 2016