Authors
David M Howard, Mark J Adams, Toni-Kim Clarke, Jonathan D Hafferty, Jude Gibson, Masoud Shirali, Jonathan RI Coleman, Saskia P Hagenaars, Joey Ward, Eleanor M Wigmore, Clara Alloza, Xueyi Shen, Miruna C Barbu, Eileen Y Xu, Heather C Whalley, Riccardo E Marioni, David J Porteous, Gail Davies, Ian J Deary, Gibran Hemani, Klaus Berger, Henning Teismann, Rajesh Rawal, Volker Arolt, Bernhard T Baune, Udo Dannlowski, Katharina Domschke, Chao Tian, David A Hinds, Maciej Trzaskowski, Enda M Byrne, Stephan Ripke, Daniel J Smith, Patrick F Sullivan, Naomi R Wray, Gerome Breen, Cathryn M Lewis, Andrew M McIntosh
Publication date
2019/3
Journal
Nature neuroscience
Volume
22
Issue
3
Pages
343-352
Publisher
Nature Publishing Group
Description
Major depression is a debilitating psychiatric illness that is typically associated with low mood and anhedonia. Depression has a heritable component that has remained difficult to elucidate with current sample sizes due to the polygenic nature of the disorder. To maximize sample size, we meta-analyzed data on 807,553 individuals (246,363 cases and 561,190 controls) from the three largest genome-wide association studies of depression. We identified 102 independent variants, 269 genes, and 15 genesets associated with depression, including both genes and gene pathways associated with synaptic structure and neurotransmission. An enrichment analysis provided further evidence of the importance of prefrontal brain regions. In an independent replication sample of 1,306,354 individuals (414,055 cases and 892,299 controls), 87 of the 102 associated variants were significant after multiple testing correction …
Scholar articles
DM Howard, MJ Adams, TK Clarke, JD Hafferty… - Nature neuroscience, 2019