Authors
Erika J Wolf, Filomene G Morrison, Danielle R Sullivan, Mark W Logue, Rachel E Guetta, Annjanette Stone, Steven A Schichman, Regina E McGlinchey, William P Milberg, Mark W Miller
Publication date
2019/8/1
Journal
Brain, behavior, and immunity
Volume
80
Pages
193-203
Publisher
Academic Press
Description
Background
Longevity gene klotho (KL) is associated with age-related phenotypes but has not been evaluated against a direct human biomarker of cellular aging. We examined KL and psychiatric stress, including posttraumatic stress disorder (PTSD), which is thought to potentiate accelerated aging, in association with biomarkers of cellular aging.
Methods
The sample comprised 309 white, non-Hispanic genotyped veterans with measures of epigenetic age (DNA methylation age), telomere length (n = 252), inflammation (C-reactive protein), psychiatric symptoms, metabolic function, and white matter neural integrity (diffusion tensor imaging; n = 185). Genotyping and DNA methylation were obtained on epi/genome-wide beadchips.
Results
In gene by environment analyses, two KL variants (rs9315202 and rs9563121) interacted with PTSD severity (peak corrected p = 0.044) and sleep disturbance (peak …
Scholar articles
EJ Wolf, FG Morrison, DR Sullivan, MW Logue… - Brain, behavior, and immunity, 2019