Authors
Laura M Huckins, Chris Chatzinakos, Michael S Breen, Jakob Hartmann, Torsten Klengel, Ana C da Silva Almeida, Amanda Dobbyn, Kiran Girdhar, Gabriel E Hoffman, Claudia Klengel, Mark W Logue, Adriana Lori, Adam X Maihofer, Filomene G Morrison, Hoang T Nguyen, Yongjin Park, Douglas Ruderfer, Laura G Sloofman, Sanne JH van Rooij, Dewleen G Baker, Chia-Yen Chen, Nancy Cox, Laramie E Duncan, Mark A Geyer, Stephen J Glatt, Hae Kyung Im, Victoria B Risbrough, Jordan W Smoller, Dan J Stein, Rachel Yehuda, Israel Liberzon, Karestan C Koenen, Tanja Jovanovic, Manolis Kellis, Mark W Miller, Silviu-Alin Bacanu, Caroline M Nievergelt, Joseph D Buxbaum, Pamela Sklar, Kerry J Ressler, Eli A Stahl, Nikolaos P Daskalakis
Publication date
2020/6/2
Journal
Cell reports
Volume
31
Issue
9
Publisher
Elsevier
Description
To reveal post-traumatic stress disorder (PTSD) genetic risk influences on tissue-specific gene expression, we use brain and non-brain transcriptomic imputation. We impute genetically regulated gene expression (GReX) in 29,539 PTSD cases and 166,145 controls from 70 ancestry-specific cohorts and identify 18 significant GReX-PTSD associations corresponding to specific tissue-gene pairs. The results suggest substantial genetic heterogeneity based on ancestry, cohort type (military versus civilian), and sex. Two study-wide significant PTSD associations are identified in European and military European cohorts; ZNF140 is predicted to be upregulated in whole blood, and SNRNP35 is predicted to be downregulated in dorsolateral prefrontal cortex, respectively. In peripheral leukocytes from 175 marines, the observed PTSD differential gene expression correlates with the predicted differences for these individuals …
Scholar articles
LM Huckins, C Chatzinakos, MS Breen, J Hartmann… - Cell reports, 2020