Authors
Erika J Wolf, Mark W Logue, Xiang Zhao, Nikolaos P Daskalakis, Filomene G Morrison, Shaline Escarfulleri, Annjanette Stone, Steven A Schichman, Regina E McGlinchey, William P Milberg, Cidi Chen, Carmela R Abraham, Mark W Miller
Publication date
2020/7/1
Journal
Psychoneuroendocrinology
Volume
117
Pages
104656
Publisher
Pergamon
Description
Background
Longevity gene klotho (KL) is associated with age-related phenotypes including lifespan, cardiometabolic disorders, cognition, and brain morphology, in part, by conferring protection against inflammation. We hypothesized that the KL/inflammation association might be altered in the presence of psychiatric stress and operate via epigenetic pathways. We examined KL polymorphisms, and their interaction with posttraumatic stress disorder (PTSD) symptoms, in association with KL DNA methylation in blood. We further examined KL DNA methylation as a predictor of longitudinal changes in a peripheral biomarker of inflammation (C-reactive protein; CRP).
Methods
The sample comprised 309 white non-Hispanic military veterans (93.5 % male; mean age: 32 years, range: 19–65; 30 % PTSD per structured diagnostic interview); 111 were reassessed approximately two years later.
Results
Analyses revealed a …
Total citations
Scholar articles
EJ Wolf, MW Logue, X Zhao, NP Daskalakis… - Psychoneuroendocrinology, 2020