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The oxygen isotopic composition of conodonts from the Pizzo Mondello section in the Sicani Basin (Sicily, Italy), on the northwestern Tethys margin, has been used to reconstruct regional paleoseawater conditions. The δ¹⁸O_phos values (21‰–21.9‰) measured by sensitive high-resolution ion microprobe (SHRIMP II) are consistent with previously published δ¹⁸O_phos data from the contemporaneous marginal Hallstatt-Meliata Basin (20.3‰–22.5‰) located farther north, but are distinctly higher than those previously reported from the open ocean setting of the nearby Lagonegro Basin (18.7‰–20.0‰). This ∼2‰ offset represents a temperature differential of ∼8 °C, suggesting that sea-surface temperatures along the northwestern margin (Sicani and Hallstatt-Meliata basins) of the Tethys Ocean were lower than in the open ocean (Lagonegro Basin) during the late Carnian (Tuvalian 2) to early Norian (Lacian …