Authors
Katja Maria Bendtsen, Louise Gren, Vilhelm Berg Malmborg, Pravesh Chandra Shukla, Martin Tunér, Yona J Essig, Annette M Krais, Per Axel Clausen, Trine Berthing, Katrin Loeschner, Nicklas Raun Jacobsen, Henrik Wolff, Joakim Pagels, Ulla Birgitte Vogel
Publication date
2020/12
Journal
Particle and Fibre Toxicology
Volume
17
Pages
1-25
Publisher
BioMed Central
Description
Background
Diesel exhaust is carcinogenic and exposure to diesel particles cause health effects. We investigated the toxicity of diesel exhaust particles designed to have varying physicochemical properties in order to attribute health effects to specific particle characteristics. Particles from three fuel types were compared at 13% engine intake O2 concentration: MK1 ultra low sulfur diesel (DEP13) and the two renewable diesel fuels hydrotreated vegetable oil (HVO13) and rapeseed methyl ester (RME13). Additionally, diesel particles from MK1 ultra low sulfur diesel were generated at 9.7% (DEP9.7) and 17% (DEP17) intake O2 concentration. We evaluated physicochemical properties and histopathological, inflammatory and genotoxic responses on day 1, 28, and 90 after single intratracheal instillation in mice compared to reference diesel particles and carbon black.
Results
Moderate variations were seen in …
Total citations
20212022202320248151412
Scholar articles
KM Bendtsen, L Gren, VB Malmborg, PC Shukla… - Particle and Fibre Toxicology, 2020