Authors
Stephen D Bentley, Keith F Chater, A-M Cerdeño-Tárraga, Greg L Challis, NR Thomson, Keith D James, David E Harris, Michael A Quail, H Kieser, David Harper, Alex Bateman, Stephanie Brown, Govind Chandra, Carton W Chen, Mark Collins, Ann Cronin, Andrew Fraser, Arlette Goble, Juan Hidalgo, Tony Hornsby, Simon Howarth, C-H Huang, Tobias Kieser, L Larke, Lee Murphy, Karen Oliver, Susan O'Neil, Ester Rabbinowitsch, M-A Rajandream, Kim Rutherford, Simon Rutter, Kath Seeger, David Saunders, Sarah Sharp, Robert Squares, Steven Squares, Kate Taylor, Tim Warren, Andreas Wietzorrek, John Woodward, Bart G Barrell, Julian Parkhill, David A Hopwood
Publication date
2002/5/9
Journal
nature
Volume
417
Issue
6885
Pages
141-147
Publisher
Nature Publishing Group UK
Description
Streptomyces coelicolor is a representative of the group of soil-dwelling, filamentous bacteria responsible for producing most natural antibiotics used in human and veterinary medicine. Here we report the 8,667,507 base pair linear chromosome of this organism, containing the largest number of genes so far discovered in a bacterium. The 7,825 predicted genes include more than 20 clusters coding for known or predicted secondary metabolites. The genome contains an unprecedented proportion of regulatory genes, predominantly those likely to be involved in responses to external stimuli and stresses, and many duplicated gene sets that may represent ‘tissue-specific’ isoforms operating in different phases of colonial development, a unique situation for a bacterium. An ancient synteny was revealed between the central ‘core’ of the chromosome and the whole chromosome of pathogens Mycobacterium tuberculosis …
Total citations
Scholar articles
SD Bentley, KF Chater, AM Cerdeño-Tárraga… - nature, 2002