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New welfare policies mandate minor, unmarried adolescent mothers to coreside with a parent or adult guardian to qualify for cash assistance. The influence of grandmother coresidence and the quality of familial relationships on adolescent mothers' psychological well-being is little understood. This article considers the main and interactive effects of grandmother coresidence, family cohesion, and young mother conflict with grandmother on adolescent reports of depressive symptoms in a sample (N = 194) of predominantly low-income adolescent mothers. Young mothers ranged in age from 15 to 17 years during pregnancy. Predictor variables' associations with depressive symptoms were examined at 6, 18, and 30 months post-partum. No main effects of grandmother coresidence on adolescents' depressive symptoms were found. In contrast, the quality of family relationships, as well as the interaction of grandmother …