Authors
Carine Karachi, Jérôme Yelnik, Dominique Tandé, Léon Tremblay, Etienne C Hirsch, Chantal François
Publication date
2005/2
Journal
Movement disorders: official journal of the Movement Disorder Society
Volume
20
Issue
2
Pages
172-180
Publisher
Wiley Subscription Services, Inc., A Wiley Company
Description
The subthalamic nucleus (STN) is the best target for correcting motor disability in parkinsonian patients with high‐frequency stimulation. However, STN stimulation has also been reported to modify cognitive, emotional, and motivational functions. The aim of this study was to analyze the topographic organization of the STN according to its inputs coming from the sensorimotor, associative, and limbic territories of the external globus pallidus (GPe) in monkeys, with special reference to the limbic projection. Axonal tracers were injected into the different functional territories of the GPe. Injection performed in the limbic GPe resulted in labeling of cell bodies in the dorsal nucleus accumbens and in a dense labeling of axons in the anterior and medioventral portion of the STN. In comparison, injections in the associative and sensorimotor GPe led to labeling in the central and dorsolateral parts of the STN, respectively …
Total citations
Scholar articles
C Karachi, J Yelnik, D Tandé, L Tremblay, EC Hirsch… - Movement disorders: official journal of the Movement …, 2005