Authors
Paul G Higgins, Hilmar Wisplinghoff, Danuta Stefanik, Harald Seifert
Publication date
2004/5
Journal
Antimicrobial agents and chemotherapy
Volume
48
Issue
5
Pages
1586-1592
Publisher
American Society for Microbiology
Description
Acinetobacter baumannii is an important nosocomial pathogen usually in the context of serious underlying disease. Multidrug resistance in these organisms is frequent. The β-lactamase inhibitors clavulanic acid, sulbactam, and tazobactam have intrinsic activity against Acinetobacter strains. To evaluate their potential therapeutic usefulness, we determined the in vitro activity of ampicillin, sulbactam, ampicillin-sulbactam, cefoperazone, cefoperazone-sulbactam, piperacillin, piperacillin-sulbactam, tazobactam, piperacillin-tazobactam, amoxicillin, clavulanic acid, amoxicillin-clavulanic acid, ticarcillin, and ticarcillin-clavulanic acid against multidrug-resistant A. baumannii. All isolates were epidemiologically characterized by RAPD [random(ly) amplified polymorphic DNA] analysis and/or pulsed-field gel electrophoresis and represented different strain types, including sporadic strains, as well as outbreak-related strains …
Total citations
Scholar articles
PG Higgins, H Wisplinghoff, D Stefanik, H Seifert - Antimicrobial agents and chemotherapy, 2004