Authors
HSM Ammerlaan, S Harbarth, AGM Buiting, DW Crook, F Fitzpatrick, Håkan Hanberger, LA Herwaldt, PHJ Van Keulen, JAJW Kluytmans, A Kola, RS Kuchenbecker, E Lingaas, N Meessen, MM Morris-Downes, JM Pottinger, P Rohner, RP Dos Santos, H Seifert, H Wisplinghoff, S Ziesing, AS Walker, MJM Bonten
Publication date
2013/3/15
Journal
Clinical infectious diseases
Volume
56
Issue
6
Pages
798-805
Publisher
Oxford University Press
Description
Background. It is unknown whether rising incidence rates of nosocomial bloodstream infections (BSIs) caused by antibiotic-resistant bacteria (ARB) replace antibiotic-susceptible bacteria (ASB), leaving the total BSI rate unaffected.
Methods. We investigated temporal trends in annual incidence densities (events per 100 000 patient-days) of nosocomial BSIs caused by methicillin-resistant Staphylococcus aureus (MRSA), ARB other than MRSA, and ASB in 7 ARB-endemic and 7 ARB-nonendemic hospitals between 1998 and 2007.
Results. 33 130 nosocomial BSIs (14% caused by ARB) yielded 36 679 microorganisms. From 1998 to 2007, the MRSA incidence density increased from 0.2 to 0.7 (annual increase, 22%) in ARB-nonendemic hospitals, and from 3.1 to 11.7 (annual increase, 10%) in ARB-endemic hospitals (P = .2), increasing the …
Scholar articles
HSM Ammerlaan, S Harbarth, AGM Buiting, DW Crook… - Clinical infectious diseases, 2013