Authors
Noriyoshi Yamamoto, Anguo Gu, Carolyn M DeRosa, Juichiro Shimizu, Donna R Zwas, Craig R Smith, Daniel Burkhoff
Publication date
2000
Journal
Lasers in Surgery and Medicine: The Official Journal of the American Society for Laser Medicine and Surgery
Volume
27
Issue
1
Pages
18-28
Publisher
John Wiley & Sons, Inc.
Description
Background and Objective
Transmyocardial revascularization (TMR) relieves angina and improves exercise tolerance in patients. Angiogenesis and myocardial denervation have been proposed as factors contributing to these benefits. To test whether radio frequency transmyocardial revascularization (RF‐TMR) enhances angiogenesis and causes myocardial denervation.
Study Design/Materials and Methods
RF‐TMR channels were created in 12 dogs which survived up to 4 weeks. Bromodeoxyuridine was administered subcutaneously to mark proliferating cells as an assay of angiogenesis. Western blot analysis of tyrosine hydroxylase and blood pressure response to topical bradykinin were used as indices of myocardial denervation.
Results
RF‐TMR increased local vascularity by an average of 50%, whereas the rate of vascular cell proliferation was tripled over that of the untreated region. Changes in mean …
Total citations
Scholar articles
N Yamamoto, A Gu, CM DeRosa, J Shimizu, DR Zwas… - Lasers in Surgery and Medicine: The Official Journal of …, 2000