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The Traveling Salesman Problem (TSP) is one of the most famous problems in combinatorial optimization. In this paper, we are going to examine how the techniques of Guided Local Search (GLS) and Fast Local Search (FLS) can be applied to the problem. GLS sits on top of local search heuristics and has as a main aim to guide these procedures in exploring efficiently and effectively the vast search spaces of combinatorial optimization problems. GLS can be combined with the neighborhood reduction scheme of FLS which significantly speeds up the operations of the algorithm. The combination of GLS and FLS with TSP local search heuristics of different eiciency and effectiveness is studied in an effort to determine the dependence of GLS on the underlying local search heuristic used. Comparisons are made with some of the best TSP heuristic algorithms and general optimization techniques which demonstrate the …