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Congenital heart defect (CHD) is one of the most serious congenital deformities in a fetus. About 31% to 55% of CHDs are the primary cause that leads to life-threatening problem among neonates, hence sonographers emphasize the importance of prenatal CHD screening. Among 18 types of CHDs, the asymmetric appearance of the heart seems to be a challenging part. Hypoplastic left heart syndrome (HLHS) is a critical and rare CHD, with an underdeveloped left heart chamber of the fetus. This prenatal CHD can be diagnosed between 17 to 21 weeks of gestation period. Though ultrasound provides a good diagnostic result, prenatal diagnosis is still a challenging area due to its speckle noise and irregular appearance of the heart chambers. In this context, the basic step is to appropriately select the pre-processing algorithm, one such algorithm is the Fuzzy based maximum likelihood estimation technique (FMLET …