Authors
Rebecca J Garten, C Todd Davis, Colin A Russell, Bo Shu, Stephen Lindstrom, Amanda Balish, Wendy M Sessions, Xiyan Xu, Eugene Skepner, Varough Deyde, Margaret Okomo-Adhiambo, Larisa Gubareva, John Barnes, Catherine B Smith, Shannon L Emery, Michael J Hillman, Pierre Rivailler, James Smagala, Miranda De Graaf, David F Burke, Ron AM Fouchier, Claudia Pappas, Celia M Alpuche-Aranda, Hugo López-Gatell, Hiram Olivera, Irma López, Christopher A Myers, Dennis Faix, Patrick J Blair, Cindy Yu, Kimberly M Keene, P David Dotson Jr, David Boxrud, Anthony R Sambol, Syed H Abid, Kirsten St. George, Tammy Bannerman, Amanda L Moore, David J Stringer, Patricia Blevins, Gail J Demmler-Harrison, Michele Ginsberg, Paula Kriner, Steve Waterman, Sandra Smole, Hugo F Guevara, Edward A Belongia, Patricia A Clark, Sara T Beatrice, Ruben Donis, Jacqueline Katz, Lyn Finelli, Carolyn B Bridges, Michael Shaw, Daniel B Jernigan, Timothy M Uyeki, Derek J Smith, Alexander I Klimov, Nancy J Cox
Publication date
2009/7/10
Journal
science
Volume
325
Issue
5937
Pages
197-201
Publisher
American Association for the Advancement of Science
Description
Since its identification in April 2009, an A(H1N1) virus containing a unique combination of gene segments from both North American and Eurasian swine lineages has continued to circulate in humans. The lack of similarity between the 2009 A(H1N1) virus and its nearest relatives indicates that its gene segments have been circulating undetected for an extended period. Its low genetic diversity suggests that the introduction into humans was a single event or multiple events of similar viruses. Molecular markers predictive of adaptation to humans are not currently present in 2009 A(H1N1) viruses, suggesting that previously unrecognized molecular determinants could be responsible for the transmission among humans. Antigenically the viruses are homogeneous and similar to North American swine A(H1N1) viruses but distinct from seasonal human A(H1N1).
Total citations
Scholar articles
RJ Garten, CT Davis, CA Russell, B Shu, S Lindstrom… - science, 2009