Authors
Shyam Gopalakrishnan, S Sunna Ebenesersdóttir, Inge KC Lundstrøm, Gordon Turner-Walker, Kristjan HS Moore, Pierre Luisi, Ashot Margaryan, Michael D Martin, Martin Rene Ellegaard, Ásgeir Sigurðsson, Steinunn Snorradóttir, Droplaug N Magnúsdóttir, Jason E Laffoon, Lucy van Dorp, Xiaodong Liu, Ida Moltke, María C Ávila-Arcos, Joshua G Schraiber, Simon Rasmussen, David Juan, Pere Gelabert, Toni de-Dios, Anna K Fotakis, Miren Iraeta-Orbegozo, Åshild J Vågene, Sean Dexter Denham, Axel Christophersen, Hans K Stenøien, Filipe G Vieira, Shanlin Liu, Torsten Günther, Toomas Kivisild, Ole Georg Moseng, Birgitte Skar, Christina Cheung, Marcela Sandoval-Velasco, Nathan Wales, Hannes Schroeder, Paula F Campos, Valdís B Guðmundsdóttir, Thomas Sicheritz-Ponten, Bent Petersen, Jostein Halgunset, Edmund Gilbert, Gianpiero L Cavalleri, Eivind Hovig, Ingrid Kockum, Tomas Olsson, Lars Alfredsson, Thomas F Hansen, Thomas Werge, Eske Willerslev, Francois Balloux, Tomas Marques-Bonet, Carles Lalueza-Fox, Rasmus Nielsen, Kári Stefánsson, Agnar Helgason, M Thomas P Gilbert
Publication date
2022/10/1
Journal
Current Biology
Publisher
Cell Press
Description
Human populations have been shaped by catastrophes that may have left long-lasting signatures in their genomes. One notable example is the second plague pandemic that entered Europe in ca. 1,347 CE and repeatedly returned for over 300 years, with typical village and town mortality estimated at 10%–40%.1 It is assumed that this high mortality affected the gene pools of these populations. First, local population crashes reduced genetic diversity. Second, a change in frequency is expected for sequence variants that may have affected survival or susceptibility to the etiologic agent (Yersinia pestis).2 Third, mass mortality might alter the local gene pools through its impact on subsequent migration patterns. We explored these factors using the Norwegian city of Trondheim as a model, by sequencing 54 genomes spanning three time periods: (1) prior to the plague striking Trondheim in 1,349 CE, (2) the 17th–19th …
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Scholar articles
S Gopalakrishnan, SS Ebenesersdottir, IKC Lundstrøm… - Current Biology, 2022